上腹部痛(Epigastric Pain)シリーズ4 RESIDENT COURSE 解答 【症例 ER 16】

(絞扼性小腸閉塞による)小腸壊死.Small bowel necrosis.



下記文献をまとめると,腸管壊死・虚血のCT所見は,1)造影CTで壁が造影されないまたは造影が弱い,2)単純CTで壁が高濃度(出血性壊死),3)遊離ガス,4)SMVまたは門脈内ガス,5)壁内気腫(intramural gas),6)壁肥厚,7)大量の腹水,8)隣接する腹膜,腸間膜や後腹膜筋膜の充血・肥厚.1,2と5が特異性が高い.
 図1と図7で腹水がある(※).拡張(外径2.5cm以上)した小腸は図2と図3の小腸(SB),図6の直腸(R)やS状結腸(S)と比較して壁の造影効果が全く認められないか,わずかに一部の壁が染まっている程度で,さらにニボー(air fluid level)を形成しない,壁に沿った線状のガス(△)は壁内気腫(intramural gas)であり壊死に陥った腸管である.手術所見は癒着と捻転による絞扼性小腸閉塞と小腸壊死であった.




参考症例:78歳男性.5日間排便がなく,腹痛と腹部膨満を訴えて来院した.肝弯曲部結腸癌による閉塞例で,腹部単純写真で上行結腸と盲腸の拡張と壁内気腫(△)を認めた.経鼻胃管を挿入し経過観察されたが,3日目に穿孔を起こし,術後敗血症を合併し2ヶ月後に死亡した.

文献考察:腸管壊死・虚血のCT所見
1)Abdom Imaging. 2004 Jan-Feb;29(1):18-22.
CT of small bowel ischemia.
Chou CK, Mak CW, Tzeng WS, Chang JM.

We evaluated the computed tomographic (CT) features of small bowel (SB) ischemia and necrosis and correlated the findings with clinical outcome or patient prognosis. Sixty-eight surgically or angiographically proved cases of SB ischemia were retrospectively reviewed. The CT features of intestinal ischemia were divided into three groups: (A) thinned bowel wall with poor enhancement, intramural gas, or portal venous gas; (B) thickened SB wall without superior mesenteric vein thrombosis; and (C) thickened SB wall with superior mesenteric vein thrombosis or intussusception. The evaluated factors included bowel wall or mucosal enhancement pattern, SB dilatation, mesenteric edema, and CT evidence of narrowing or occlusion of the superior mesenteric artery or vein. The bowel necrosis rates and mortalities were compared with chi-square test. Oral contrast material was not administered. Intramural gas and SB dilatation were associated with a higher bowel necrosis rate (eight of eight, 100%, and 17 of 21, 81%, respectively) in group A. Poor mucosal enhancement of the thickened bowel wall indicated a higher bowel necrosis rate in groups B (six of seven, 86%) and C (12 of 12, 100%) than did normal mucosal enhancement. Only intramural gas was accompanied with a higher mortality (six of eight, 75%). Intramural gas of a thinned bowel wall and poor mucosal enhancement of a thickened small bowel wall are useful signs of bowel necrosis. Intramural gas would indicate poor patient prognosis.PMID: 15160748

2)Eur Radiol. 2004 Dec;14(12):2347-56.
Accuracy of multidetector row computed tomography for the diagnosis of acute bowel ischemia in a non-selected study population.
Wiesner W, Hauser A, Steinbrich W.

The diagnostic accuracy of multidetector row computed tomography for the prospective diagnosis of acute bowel ischemia in the daily clinical routine was analyzed. Two hundred ninety-one consecutive patients with an acute or subacute abdomen, examined by MDCT over a time period of 5 months, were included in the study. All original CT diagnoses made during the daily routine by radiological generalists were compared to the final diagnoses made by using all available medical information from endoscopies, surgical interventions, autopsies and follow-up. Finally, all CT examinations of patients with an initial CT diagnosis or a final diagnosis of bowel ischemia were reread by a radiologist specialized in abdominal imaging in order to analyze the CT findings and the reasons for initially false negative or false positive CT readings. Twenty-four patients out of 291 (8.2%) had acute bowel ischemia. The age of affected patients ranged from 50 to 94 years (mean age: 75.7 years). Eleven patients were male, and 13 female. Reasons for acute bowel ischemia were: arterio-occlusive (n=11), non-occlusive (n=5), strangulation (n=2), over-distension (n=3) and radiation (n=3). The prospective sensitivity, specificity, PPV and NPV of MDCT for the diagnosis of acute bowel ischemia in the daily routine were 79.17, 98.51, 90.48 and 98.15%. MDCT reaches a similarly high sensitivity in diagnosing acute bowel as angiography. Furthermore, it has the advantage of being helpful in most of its clinical differential diagnoses and of being less invasive with the consecutive possibility of being used earlier in the diagnostic process with all the resulting positive effects on the patients prognosis. Therefore, nowadays MDCT should probably be used as the first step imaging modality of choice in patients with suspected acute bowel ischemia.PMID: 15378337

3)Radiographics. 2001 Nov-Dec;21(6):1463-73.
Multi-detector row CT of mesenteric ischemia: can it be done?
Horton KM, Fishman EK.

Mesenteric ischemia is a complicated disorder whose prevalence in the United States is increasing as the population ages. It is often difficult to diagnose, both clinically and radiologically. In the past, computed tomography (CT) has allowed only limited success in the early detection of ischemia. However, with the introduction of multi-detector row CT and three-dimensional (3D) imaging, it is now possible to perform a detailed CT examination of the small bowel and mesenteric vessels. Multi-detector row CT allows routine studies to be performed much faster than with single-detector CT scanners and makes available new applications, especially in the field of CT angiography. Its increased speed and narrower collimation, coupled with the use of water as an oral contrast agent, improve visualization of the bowel wall and mesenteric vasculature. Multi-detector row CT with 3D reformatting may improve the ability to make an early diagnosis and identify the cause of disease in patients with suspected acute or chronic mesenteric ischemia. In many cases, this examination has eliminated the need for additional imaging studies such as Doppler ultrasonography or angiography. Further investigation will be needed to determine the scope of the utility of multi-detector row CT in this clinical setting.PMID: 11706217 (full text)

4)Radiographics. 2000 Jan-Feb;20(1):29-42.
CT and MR imaging findings of bowel ischemia from various primary causes.
Rha SE, Ha HK, Lee SH, Kim JH, Kim JK, Kim JH, Kim PN, Lee MG, Auh YH.

Ischemic bowel disease represents a broad spectrum of diseases with various clinical and radiologic manifestations, which range from localized transient ischemia to catastrophic necrosis of the gastrointestinal tract. The primary causes of insufficient blood flow to the intestine are diverse and include thromboembolism, nonocclusive causes, bowel obstruction, neoplasms, vasculitis, abdominal inflammatory conditions, trauma, chemotherapy, radiation, and corrosive injury. Computed tomography (CT) or magnetic resonance (MR) imaging can demonstrate the ischemic bowel segment and may be helpful in determining the primary cause. The CT and MR imaging findings include bowel wall thickening with or without the target sign, intramural pneumatosis, mesenteric or portal venous gas, and mesenteric arterial or venous thromboembolism. Other CT findings include engorgement of mesenteric veins and mesenteric edema, lack of bowel wall enhancement, increased enhancement of the thickened bowel wall, bowel obstruction, and infarction of other abdominal organs. However, regardless of the primary cause, the imaging findings of bowel ischemia are similar. Furthermore, the bowel changes simulate inflammatory or neoplastic conditions. Understanding the pathogenesis of various conditions leading to mesenteric ischemia helps the radiologist recognize ischemic bowel disease and avoid delayed diagnosis, unnecessary surgery, or less than optimal management.PMID: 10682769 (full text)

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